Step 1: Preheat your oven to 350°F (175°C). Grease and flour a 9×5-inch loaf pan or line it with parchment paper for easy removal.
Step 2: In a large mixing bowl, beat together the softened cream cheese and butter until smooth and creamy, about 2-3 minutes.
Step 3: Gradually add the granulated sugar and mix until well combined. Then, add the eggs one at a time, beating well after each addition.
Step 4: Stir in the lemon zest, fresh lemon juice, and vanilla extract until fully incorporated.
Step 5: In a separate bowl, whisk together the flour, baking powder, baking soda, and salt.
Step 6: Gradually add the dry ingredients to the wet mixture, stirring until just combined. Be careful not to overmix; a few lumps are okay.
Step 7: Pour the batter into the prepared loaf pan, smoothing the top with a spatula.
Step 8: Place the loaf pan in the preheated oven and bake for 55-65 minutes, or until a toothpick inserted into the center comes out clean.
Step 9: Once baked, remove the bread from the oven and let it cool in the pan for about 10 minutes. Then, transfer it to a wire rack to cool completely before slicing.