Step 1: In a large bowl, gently combine the ground beef, Italian seasoning, garlic powder, onion powder, salt, and black pepper. Divide the seasoned meat into 8 equal portions. Form each portion into a thin, round patty, about 4 inches in diameter.
Step 2: Place a generous tablespoon of shredded mozzarella cheese and a teaspoon of pizza sauce in the center of four of the patties. Leave a small border around the edge.
Step 3: Carefully place the remaining four patties on top of the cheese and sauce-filled patties. Pinch the edges together firmly to seal the filling inside. Gently reshape the patties to about 3.5 inches in diameter and about 1 inch thick. Make a small indentation in the center of each patty with your thumb.
Step 4: Preheat your grill or a large cast-iron skillet over medium-high heat. Lightly brush the grill grates or skillet with a high smoke point oil.
Step 5: Place the stuffed patties on the hot grill or in the skillet. Cook for 4-6 minutes per side, depending on your desired doneness (internal temperature should reach 160°F or 71°C).
Step 6: While the burgers are cooking, lightly toast your burger buns.
Step 7: Once the burgers are cooked, remove them from the heat and let them rest for 2-3 minutes.
Step 8: Assemble your mozzarella stuffed pizza burgers! Spread a little extra pizza sauce on the bottom bun. Place a burger patty on top, then add your favorite pizza toppings and a sprinkle of extra mozzarella. Top with the top bun and serve immediately.